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This report analyzes the worldwide markets for Biochips in US$ Million by the following Product Segments: DNA Chips, Protein Chips, and Lab Chips. Annual estimates and forecasts are provided for the period 2009 through 2017. Also, a six-year historic analysis is provided for these markets. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia Pacific, Middle East, and Latin America. The report profiles 77 companies including many key and niche players such as Affymetrix Inc., Agilent Technologies, Inc., Bio-Rad Laboratories, Inc., Caliper Life Sciences, Inc., Cepheid Inc., Fluidigm Corporation, GE Healthcare Ltd., Illumina, Inc., Life Technologies Corporation, Ocimum Biosolutions Ltd., Takara Bio, Inc., Clontech Laboratories, Inc., and Zyomyx, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based upon search engine sources in the public domain.
I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONSStudy Reliability and Reporting Limitations I-1Disclaimers I-2Data Interpretation & Reporting Level I-3Quantitative Techniques & Analytics I-3Product Definitions and Scope of Study I-3A. DNA Chips I-3B. Protein Chips I-4C. Lab Chips I-4II. EXECUTIVE SUMMARY
1. INDUSTRY OVERVIEW II-1
A Primer II-1
Recession Dries Up Funds for Biotech Firms II-1
Promising Biochips Promote Biological Research II-2
Key Forces Driving the Industry II-3
DNA Chips Lead the Application Front II-3
Protein Biochips - Set for Robust Expansion II-3
Lab-on-a-Chips: Fusion of Nanotechnology & Genetic Engineering II-4
Industry Challenges II-4
Standardization: A Key Challenge II-4
Price Dearness Pauses Biochips Growth II-5
2. MARKET DYNAMICS II-6Current Approaches to Biochips II-6The Business of Biochips II-6Technological Differentiation in Demand II-7Focus on Highly Intelligent Diagnostic Systems II-7Scalability & Pricing - Focus Areas II-7Biochips: Expanding Role in Diagnostic Medicine II-8Advancements in Biochip Technology II-8Biochip Technology Boosts Personalised Medicine II-9Biochip Technology Spreads beyond Pharma Industry II-9Proteomics "Chip" into Biochip Technology II-10Towards Increasing Minaturization II-10Technological Trends II-10Sensitivity II-10Microfabrication II-10Density II-11Integrated Chips II-11Patent Trends II-11Table 1: Number of Lab-on-a-Chip Patents (includescorresponding Graph/Chart) II-11
Table 2: % of Lab-on-a-Chip Patent Documents by
Country/Authority of Origin (January 2008 - April 2009)
(includes corresponding Graph/Chart) II-12
Table 3: Number of Lab-on-a-Chip Documents by PatentAssignees (January 2008 - April 2009) (includescorresponding Graph/Chart) II-12Patent Applications II-13
3. COMPETITION II-14
Industry Structure II-14
Major Participants II-14
Affymetrix: A Major Market Player II-14
Growing Partnerships between Pharma and Biotech Companies II-14
Tech Giants Join the Biochip Fray II-15
4. PRODUCT OVERVIEW II-17Biochips - Complex Blend of Biochemistry and Electronics II-17Historical Perspective II-17Lab-on-a-chip: An Enabled Technology II-19Utility II-19Evolution and Segmentation II-19Differing Perspectives II-19Classification of Biochips II-20Need for Biochips II-21Manufacturing Systems Used in Biochip Manufacture II-21Working of a Biochip II-22DNA Transcription & Translation Through A Biochip II-22A Functional Model II-22Cocktail of Disparate Technically Specialized Applications II-23Biochips: By-product of Multi-disciplinary Sciences II-23Nanotechnology II-23BioMEMS II-23Microfluidics II-24Micro Total Analysis System II-24
5. BIOCHIP AND MICROARRAY CONSTRUCTION II-26
Chip Architecture II-26
Essence of a Biochip II-26
Concept of a Microarray II-26
Microarray Modules II-26
High Degree of Automation Spurs Biochips Use II-27
Microfabrication Technology in Biochips made from Polymer and
Plastics II-27
Micro-optics in Biochips II-28
Liquid Handling Through Micro-Dispensers II-28
Capillary Electrophoresis and Electrochemical Detectors II-28
Other Technologies II-28
Management of Bio-information II-28
Scanning II-29
Microarray Database Management II-29
Classification of DNA Chips II-29
General Description of Spotted cDNA Microarrays II-29
Spotted DNA Arrays II-30
Spotted cDNA Versus Spotted Oligonucleotide Arrays II-30
Limitations of Conventional cDNA Microarrays II-30
Protein Biochips II-31
General Applications of Protein Biochips II-31
Challenges in the Design of a Protein Biochip II-32
Limitations of Protein Chip Technology II-32
Concluding Remarks for Protein Biochips II-33
6. APPLICATIONS OF BIOCHIPS II-34Biochip Uses II-35Pharmaceutical Investigation II-35Medical Diagnostics II-35Advantages of Biosensor Chip Technology II-36Forensics II-36Transplantation Screening II-36Identity Testing II-36Water and Environmental Testing II-37Food Industry II-37
7. PRODUCT INNOVATIONS/INTRODUCTIONS II-38
Randox Launches Evidence Evolution Analyzer II-38
South Korea Develops Instant Microfluidic Biochip II-38
Fluidigm Introduces Reusable FR48.48 Dynamic Array™ IFC II-38
Cellix Introduces Vena4Y™ and Vena4Y2™ Biochips II-38
Agilent Technologies Unveils Workflow HPLC-Chip II-39
Febit Holding Introduces First Human Cancer Biochip II-39
Blue4Green Rolls Out Lab-on-a-chip Solution II-40
Randox Laboratories Unveils Biochip Arrays II-40
Randox Laboratories Introduces Evidence Investigator II-40
Randox Unveils Innovative DoA Biochips for Rapid Drug Screening II-41
Randox Launches Revolutionary Biochip Analyser for Multiple
Cardiac Testing II-41
Febit Unveils Biochip for DNA/RNA Detection and Enrichment on
Mouse Genome II-42
Veredus Laboratories Launches Portable Test Kit for H1N1 Flu II-42
Randox Develops Multi Marker Cardiac Biochip Array for MI
Diagnosis II-42
VigeneTech and CapitalBio Launch Completely Integrated
Microarray Solution Platform II-43
8. PRODUCT INNOVATIONS/INTRODUCTIONS - A HISTORIC PERSPECTIVE BUILDER II-44Randox Introduces New Biochip Array for CAMs Testing II-44Cellix Announces Global Launch of VenaEC Biochip II-44Decision Biomarkers Rolls Out AVANTRA™ Biomarker WorkstationSystem II-44Osaka Develops Biocompatible Monomers for Biochips II-45Iris BioTechnologies Launches New Nano-Biochip II-45Affymetrix Introduces Complete Cytogenetic Solution II-45Agilent Unveils 244K CGH Micro-Array II-46Randox Unveils World's First Protein Biochip II-46Randox Introduces Thyroid Array Biochip II-46Sigma Launches ChIP Kit II-46Randox Develops Biochip for Synthetic Steroids II-47US and Czech Scientists to Develop Biochips for Detecting Cancer II-47Manchester University Researchers Develop New Protein ChipsManufacturing Procedure II-47febit Introduces New Geniom Biochip II-48Agilent Introduces Additions to the HPLC-Chip Line for Proteomics II-49Progenika Develops BLOODchip II-49Roche Introduces Gene Expression Services and Arrays II-49Stratos Biosystems Develops New EC-Affinity Biochips II-50Affymetrix Unveils Affymetrix GeneChip Command Console Software II-50Affymetrix Introduces GeneChip Mouse and Rat Gene 1.0 ST Arrays II-50Affymetrix Unveils Genome-Wide Human SNP Array 6.0 II-51Caliper Life Sciences Launches High Throughput RNA Assay II-51Applied Biosystems Unveils DNA Tools II-52febit Launches Geniom RT Analyzer II-52Austrian Research Center Develops New Biochip Surface II-52Researchers Develop Biochips to Eliminate Animal Testing II-53Progenika Biopharma Launches IBD DNA II-53Bioident Develops New Lab-on-a-Chip Nanotiter Plate Prototype II-53Ilochip and University of Denmark Develop a Biochip for FasterBird Flu Detection II-54CombiMatrix Develops a Biochip for Leukemia Analysis II-54Affymetrix Launches New Tiling Arrays for Mapping Whole-GenomeTranscript II-54Roche Plans to Launch AmpliChip in Japan II-54Caliper Life Sciences Unveils Desktop Profiler II-55Massachusetts Institute of Technology Develops Portable Lab ona Chip II-55Optical Device to Develop Lab-on-a-Chip II-55Agilent Launches Five New HPLC Chips II-56Protagen AG Launches New Protein Biochips II-56Fluidigm Releases the 8.96 TOPAZ Screening Chip II-56Affymetrix Releases Chip-on-Chip Array II-56DNA Chip Research Launches High Sensitivity DNA Chip II-56DNA Chip Research and HitachiSoft Unveils AceGene II-56
9. RECENT INDUSTRY ACTIVITY II-57
PerkinElmer Acquires Caliper Life Sciences II-57
Philips and bioMerieux to Produce Biochips for Cardiovascular
Assays II-57
Roche Diagnostics and CapitalBio to Sign MOU II-57
SVTC Partners with TSMC to Commercialize New Technologies II-58
HORIBA Jobin Yvon Takes Over GenOptics II-58
GWC Technologies to Receive $100,000 Federal Grant II-58
febit to Receive Funds for Biomarker Project II-59
Researchers Assess TB-Biochip MDR Test System II-59
IBM to Use DNA Chip for Developing Personalized Medicine II-59
10. STRATEGIC CORPORATE DEVELOPMENTS - A HISTORIC PERSPECTIVE BUILDER II-60Invitrogen and Applied Biosystems Merge to Form LifeTechnologies Corporation II-60China Medical Technologies Signs Agreement with MolecularDiagnostics Technologies II-60DNA Chip Acquires HuBit's Gene Analysis Business II-60Affymetrix Acquires USB II-61Roche NimbleGen Forms Alliance with BioDiscovery to ProvideCGH Solutions II-61Illumina Announces Partnership with Genpathway for ChIPSequencing Services II-61Jiangsu and IMDi Diagnosis to Establish Joint Venture II-62Plexera Biosciences Enters into an Option Deal with Auguron II-62Affymetrix and Avesthagen Enter into an Agreement II-63Roche NimbleGen and Affymetrix Announce Expansion of LicenseAgreement II-63Proteomika and Auguron Biosciences Ink Option Agreement II-63Gentel Biosciences and Eppendorf Enter into Global LicenseAgreement II-64GATC Biotech Establishes New Subsidiary II-64Procognia Spins off Sense Proteomic II-65Johns Hopkins University Purchases MassARRAY System II-65Yale University Purchases MassARRAY System II-65Korea's NIH Extends KARE Project with Affymetrix Technology II-65febit Obtains US Patent for Hybselect, a MicrofluidicExtraction Method II-66Atotech Enters into Research Collaboration with University ofAlbany II-66CapitalBio and Beijing National Engineering Research CenterDevelop New Biochip Testing System II-66Roche Takes Over NimbleGen II-67GenTel BioSciences Acquires Protein Chip Platform Assets of GSK II-67Advanced Liquid Logic Acquires Nanolytics II-68Applied Microarrays Acquires Select GE Healthcare's Assets II-68Canon, Toshiba and Other Companies to Join Hands for Biochips II-69BioChip Innovations Signs Research Collaboration Agreementwith IME II-69Protagen Enters into a Partnership to Develop Antibodies II-69Spanish Society of Rheumatology Enters into Collaboration withProgenika II-70Affymetrix and Partners Healthcare Extend Collaboration II-70Agencourt, NuGEN and Affymetrix Clinical Services Collaborate II-70Affymetrix Inks Licensing Agreement with Empire Genomics II-71Caliper Enters into a Licensing Agreement with MonogramBiosciences II-71Affymetrix and IPSOGEN Sign Agreement II-72bioMérieux and NuGEN Enter into Supply and Cross-LicenseAgreement II-72VWR and CapitalBio Enter into a Distribution Agreement II-73C3B Bags Contract from Department of Defense to Develop anImplantable Biochip II-73UCL Subsidiary and Roche Diagnostics Ink Licensing Deal II-73Affymetrix Establishes the European Cytogenetic ResearchInitiative II-74Fluidigm Establishes New Development Center II-74Daiichi Pure Chemicals Applies for Approval to Market DNAMicro-array II-74GE Healthcare Snaps Up Biacore II-75Bio-Rad Acquires Ciphergen's Life Science Research Business II-75Sysmex to Form Partnership with Affymetrix II-75Daiichi, Toshiba Hokuto and Toshiba Join Hands II-75Affymetrix Collaborates with Zhejiang California NanosystemInstitute II-76Merck Sharp & Dohme and Shanghai Biochip Enter into Co-operation Agreement II-76Toshiba Signs Licensing Agreement with Antara BioSciences II-77MUSC Signs LOI with Lumera II-77AVIVA Inks Agreement with Japan 's Cosmo Bio II -77Lumera Signs Collaborative Agreement with Harvard Medical School II-77Whatman Receives CE Mark for CombiChip II-78IDIBAPS Led Project Receives Approval from European Union II-78Toray to Establish DNA Chip Business II-79Protagen Forays into the US Market II-79Biacore Expands Operations into Chinese Market II-79Nisshinbo to Replace Glass with Resin in DNA Production II-79
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