SAN DIEGO—(BUSINESS WIRE)—February 4, 2009— Accelrys, Inc. (NASDAQ: ACCL) today reported financial results for its fiscal third quarter ended December 31, 2008.

In commenting on the quarter, Todd Johnson, Accelrys’ interim President and Chief Executive Officer, stated: “We are pleased with our financial results as revenue, income and cash have all increased compared to the prior year. While we recognize that the global macroeconomic climate may dampen our growth prospects in the near future, we continue to believe that our strong balance sheet and market-leading scientific operating platform products position us for long-term success. To that end, we have continued to see growth in these products this quarter and have strengthened our market-leading position with the release of our Pipeline Pilot Enterprise Server™ 7.5 software suite, which includes enhanced features to better meet our customers’ enterprise-level needs.”

Third Quarter 2009 Financial Results:

• Revenue for the quarter ended December 31, 2008 increased 5% to $20.6 million from $19.6 million for the same quarter of the previous year.
• Non-GAAP operating income was $2.3 million for the current quarter compared to a non-GAAP operating loss of $0.5 million for the same quarter of the previous year. GAAP operating income for the current quarter was $0.8 million compared to a GAAP operating loss of $2.0 million for the same quarter of the previous year.
• Non-GAAP net income was $2.5 million, or $0.09 per diluted share, for the current quarter compared to non-GAAP net income of $0.2 million, or $0.01 per diluted share, for the same quarter of the previous year. GAAP net income was $1.0 million, or $0.04 per diluted share, for the current quarter compared to a GAAP net loss of $1.2 million, or ($0.05) per diluted share, for the same quarter of the previous year.

Fiscal 2009 Year to Date Financial Results:

• Revenue for the nine months ended December 31, 2008 increased 3% to $61.0 million from $59.3 million for the same period of the previous year.
• Non-GAAP operating income was $7.3 million for the nine months ended December 31, 2008 compared to non-GAAP operating income of $4.2 million for the same period of the previous year. GAAP operating income for the nine months ended December 31, 2008 was $2.2 million compared to GAAP operating income of $0.1 million for the same period of the previous year.
• Non-GAAP net income was $7.4 million, or $0.27 per diluted share, for the nine months ended December 31, 2008 compared to non-GAAP net income of $6.0 million, or $0.22 per diluted share, for the same period of the previous year. GAAP net income was $2.3 million, or $0.09 per diluted share, for the nine months ended December 31, 2008 compared to GAAP net income of $1.8 million, or $0.07 per diluted share, for the same period of the previous year.

Recent Business Highlights:

• Released Pipeline Pilot Enterprise Server™ 7.5 Platform for Scientific Research Informatics
• Appointed Mr. Todd Johnson to serve as the Company’s President and Chief Executive Officer
• Announced an OEM agreement pursuant to which Becton Dickinson will integrate portions of the Company’s scientific operating platform into their high content analysis product line

Non-GAAP Financial Measures:

This press release describes financial measures for operating income (loss), net income, and net income per share that exclude stock-based compensation expense, purchased intangible assets amortization and restructuring charges. These financial measures are not calculated in accordance with generally accepted accounting principles (GAAP) and are not based on any comprehensive set of accounting rules or principles.

Management believes these non-GAAP financial measures provide a useful measure of the Company’s operating results, a meaningful comparison with historical results and with the results of other companies, and insight into the Company’s ongoing operating performance. Further, management and the Board of Directors utilize these measures, in addition to GAAP measures, when evaluating and comparing the Company’s operating performance against internal financial forecasts and budgets. These non-GAAP financial measures should not be considered as a substitute for, or superior to, measures of financial performance prepared in accordance with GAAP. In addition, these non-GAAP financial measures may be different from non-GAAP financial measures used by other companies.

For additional information on the items excluded by the Company from its non-GAAP financial measures please refer to the Form 8-K regarding this release that was furnished today to the Securities and Exchange Commission.

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