10.43 Callisto Pharmaceuticals 1628

10.44 Cambrex 1632

10.45 CanBas 1636

10.46 Cancer Research Technology 1641

10.47 Catalyst Biosciences 1654

10.48 Celgene 1661

10.49 Cell Therapeutics 1672

10.50 CellCeutix 1676

10.51 Celleron 1680

10.52 Cephalon 1686

10.53 CerRx 1696

10.54 Chroma Therapeutics 1701

10.55 Circadian Technologies 1708

10.56 Cleveland BioLabs 1713

10.57 Clinical Data 1719

10.58 CompleGen 1724

10.59 Compugen 1730

10.60 CoNCERT Pharmaceuticals 1737

10.61 Curis 1745

10.62 Cyclacel 1753

10.63 Cylene Pharmaceuticals 1763

10.64 Cytokine PharmaSciences 1769

10.65 Cytopia 1774

10.66 Daiichi Sankyo 1779

10.67 Dainippon Sumitomo Pharma 1785

10.68 Debiopharm 1790

10.69 Deciphera Pharmaceuticals 1794

10.70 DeveloGen 1808

10.71 DiaMedica 1815

10.72 Dyax 1819

10.73 Eisai 1823

10.74 Elara Pharmaceuticals 1832

10.75 Eli Lilly 1838

10.76 Enkam Pharmaceuticals 1862

10.77 EntreMed 1867

10.78 Enzon 1873

10.79 Erimos 1879

10.80 Exelixis 1884

10.81 Galapagos 1912

10.82 Galena Biopharma 1917

10.83 Generex 1924

10.84 Gilead Sciences 1930

10.85 GlaxoSmithKline 1936

10.86 GlycoGenesys 1962

10.87 GPC Biotech 1967

10.88 Hanmi 1974

10.89 Hoffmann-La Roche 1988

10.90 Hutchison China MediTech 2016

10.91 Hypha Discovery 2024

10.92 Idera Pharmaceuticals 2032

10.93 ImClone Systems 2036

10.94 ImmunoFrontier 2042

10.95 Incozen Therapeutics 2048

10.96 Incyte Corporation 2054

10.97 Inhibiton Therapeutics 2062

10.98 Inovio 2066

10.99 Insmed 2072

10.100 Insys Therapeutics 2078

10.101 Intellikine 2084

10.102 Isis Pharmaceuticals 2094

10.103 ISU ABXIS 2099

10.104 Jina Pharmaceuticals 2106

10.105 Johnson & Johnson 2110

10.106 Kadmon 2121

10.107 KAI Pharmaceuticals 2126

10.108 KaloBios 2131

10.109 Kalypsys 2136

10.110 Karus Therapeutics 2141

10.111 Keryx Biopharmaceuticals 2145

10.112 Kiadis 2152

10.113 Kinex 2159

10.114 Kirin Pharma 2164

10.115 KuDOS 2172

10.116 Kyowa Hakko Kirin 2177

10.117 Leo 2187

10.118 Lexicon Pharmaceuticals 2192

10.119 Ligand 2196

10.120 Marina Biotech 2201

10.121 MaxoCore Pharmaceuticals 2206

10.122 Meda 2210

10.123 Medisyn Technologies 2217

10.124 Merck & Co 2224

10.125 Merck KGaA 2243

10.126 Merrimack 2249

10.127 MethylGene 2253

10.128 Micromet 2259

10.129 Mitsubishi Tanabe Pharma 2265

10.130 Molecular LogiX 2274

10.131 Myrexis 2279

10.132 Nano Terra 2283

10.133 Nerviano Medical Sciences 2287

10.134 NexusPharma 2301

10.135 NicOx 2305

10.136 Nidus Laboratories 2309

10.137 NIH 2315

10.138 Nippon Shinyaku 2320

10.139 Non-industrial Sources 2325

10.140 NovaLead 2329

10.141 Novartis 2336

10.142 Novogen 2375

10.143 Oncalis 2385

10.144 Onconova 2391

10.145 OncoTherapy Science 2402

10.146 Oncothyreon 2408

10.147 OSI Pharmaceuticals 2418

10.148 Pathway Therapeutics 2427

10.149 Peregrine Pharmaceuticals 2436

10.150 Pfizer 2443

10.151 Pharmacyclics 2496

10.152 PharmaGap 2501

10.153 PharmaMar 2507

10.154 Pharmexa 2514

10.155 Phoenix Biotechnology 2521

10.156 PHusis Therapeutics 2525

10.157 Pieris 2531

10.158 Piramal 2538

10.159 PIramed 2544

10.160 Portola Pharmaceuticals 2551

10.161 Proacta 2557

10.162 Progenics Pharmaceuticals 2562

10.163 Provid 2566

10.164 QLT 2570

10.165 Quantum Pharmaceuticals 2577

10.166 Ras Therapeutics 2584

10.167 Reata Pharmaceuticals 2588

10.168 Receptor BioLogix 2594

10.169 Rexahn 2598

10.170 Rigel 2610

10.171 Samtheo Biopharma 2620

10.172 Sanofi 2627

10.173 Sareum 2636

10.174 SBI Biotech 2648

10.175 SBIO 2653

10.176 Scancell 2663

10.177 Schering-Plough 2668

10.178 Selvita 2675

10.179 Semafore Pharmaceuticals 2681

10.180 Sentinel Oncology 2691

10.181 SGX Pharmaceuticals 2697

10.182 Silence Therapeutics 2702

10.183 Sunesis 2707

10.184 Supratek Pharma 2717

10.185 Swedish Orphan Biovitrum 2722

10.186 Switch Pharma 2727

10.187 Symphogen 2734

10.188 Takeda 2738

10.189 Tamir Biotechnology 2757

10.190 Targa Therapeutics 2761

10.191 TargeGen 2767

10.192 TauTaTis 2772

10.193 TCD Pharma 2776

10.194 Tekmira Pharmaceuticals 2780

10.195 Telik 2786

10.196 Teva 2800

10.197 Thallion Pharmaceuticals 2810

10.198 Theryte 2816

10.199 Tigris Pharmaceuticals 2821

10.200 ToolGen 2826

10.201 TopoTarget 2830

10.202 Tragara Pharmaceuticals 2838

10.203 TransTech Pharma 2842

10.204 UCB 2847

10.205 VasGene Therapeutics 2855

10.206 Velacor Therapeutics 2859

10.207 Vernalis 2865

10.208 Vertex Pharmaceuticals 2870

10.209 VioQuest 2880

10.210 ViroMed 2887

10.211 Wyeth 2893

10.212 Xcovery 2901

10.213 Xencor 2920

10.214 YM BioSciences 2927

10.215 Zenyaku Kogyo 2933

11 Disclaimer 2940

 

4.1 List of Figures

Figure 1: Visualization of Target-Target Interactions among Targets of Protein Kinase Drugs in Oncology 442

Figure 2: The Drug-Target Competitive Landscape of Protein Kinase Drugs in Oncology - Super Cluster 444

Figure 3: The Drug-Target Competitive Landscape Protein Kinase Drugs in Oncology - Smaller Clusters 445

Figure 4: Head-to-Head Targeting Competitive Landscape of Protein Kinase Drugs in Oncology 1 (2) 446

Figure 5: Head-to-Head Targeting Competitive Landscape of Protein Kinase Drugs in Oncology 2 (2) 447

Figure 6: Distribution of Compound Strategies among Protein Kinase Cancer Drugs 1006

Figure 7: Primary Sub-cellular Localization of Drug Targets 1007

Figure 8: Number of Companies per Ranking Level 1233

 

4.2 List of Tables

Table 1: Cancer Highlights'™ Five Pillar Drug Assessment 7

Table 2: Breakdown of the Included Protein Kinase Drug Pipeline in Oncology by Stage of Development 38

Table 3: Head to Head Target Competition among Protein Kinase Drugs in Oncology 38

Table 4: Overview of Drug Target Strategy Themes 43

Table 5: Terminally Ceased Targets of Protein Kinase Drugs in Oncology 44

Table 6: Official Gene Name to Target Profle 45

Table 7: Targets of Protein Kinase Drugs in Oncology Present in the Catalogue of Somatic Mutations in Cancer and in the Cancer Gene Census 430

Table 8: Identity of Drug Targets with Available Biological Structures 435

Table 9: Number of Target-Target Interactions among Targets of Protein Kinase Drugs in Oncology 440

Table 10: Available Protein Expression Profiles of Protein Kinase Drug Targets in Oncology 448

Table 11: Pathway Summary 453

Table 12: Drug Targets without any Identified Assigned Pathways 453

Table 13: Pathway Profiles According to BioCarta of Protein Kinase Drug Targets in Oncology 455